ChroMo

Interactive and unsupervised analysis of Chromosome Movements in meiosis

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First, data. Everything welcome.

You want to analyze the position and morphology of chromosomes from various cells recorded in vivo. Just upload your measurements from Fiji (or any other tool) in CSV, TSV or XLSX format.

ChroMo first tab, data upload, with a selected example.

Next, segments. And compare.

Within the time series uploaded, segments are discovered in each of the variables specified. Later, segments are collected and classified into behavioral clusters.

Segmentation of time-series for two biological conditions, across linear and angular velocity

Then, motifs. See for yourself.

Motif (discord) analysis is a tool to consider value sequences and find the most common patterns (and discrepancies) that may appear, at any location.

Motif Discovery Plot for a time series of y-axis position

And lastly, causality. All connected.

In ChroMo, we have selected a set of algorithms that allow the study of causality relations across all user-defined variables; that is, whether changes in one variable at a time can explain changes in other variable at a later time.

Interactive Causality Graph, within an iframe

Available instances


ChroMo S

Small-tier instance

  • 256 MB RAM
  • 0.25 CPU
  • 0 /12 active instances

ChroMo M

Medium-tier instance

  • 512 MB RAM
  • 0.50 CPU
  • 0 /6 active instances

ChroMo L

Large(r)-tier instance

  • 1024 MB RAM
  • 0.75 CPU
  • 0 /2 active instances

Learn more

If you are looking for an in depth explanation of ChroMo and how we used it to explore Chromosome Movements in S. pombe, please read our paper.
Segmentation of time-series for two biological conditions, across linear and angular velocity

If you use ChroMo for your analysis, please cite us:

MDPI and ACS Style

León-Periñán, D.; Fernández-Álvarez, A. ChroMo, an Application for Unsupervised Analysis of Chromosome Movements in Meiosis. Cells 2021, 10, 2013. https://doi.org/10.3390/cells10082013

AMA Style

León-Periñán D, Fernández-Álvarez A. ChroMo, an Application for Unsupervised Analysis of Chromosome Movements in Meiosis. Cells. 2021; 10(8):2013. https://doi.org/10.3390/cells10082013

Chicago/Turabian Style

León-Periñán, Daniel, and Alfonso Fernández-Álvarez. 2021. "ChroMo, an Application for Unsupervised Analysis of Chromosome Movements in Meiosis" Cells 10, no. 8: 2013. https://doi.org/10.3390/cells10082013

BibTeX

@article{LenPerin2021,
  doi = {10.3390/cells10082013},
  url = {https://doi.org/10.3390/cells10082013},
  year = {2021},
  month = aug,
  publisher = {{MDPI} {AG}},
  volume = {10},
  number = {8},
  pages = {2013},
  author = {Daniel Le{\'{o}}n-Peri{\~{n}}{\'{a}}n and Alfonso Fern{\'{a}}ndez-{\'{A}}lvarez},
  title = {{ChroMo},  an Application for Unsupervised Analysis of Chromosome Movements in Meiosis},
  journal = {Cells}
}